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Cayman Ast-487; Purity- Greater Than Or Equal To 98%; Size- 5 Mg
NETA PART: | CAYM-19477-5 |
MFG.PART: | 19477-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
AST-487 is an inhibitor of RET (IC50 = 0.88 µM), FLT3 (Ki = 0.52 µM), KDR (IC50 = 0.17 µM), c-Abl (IC50 = 0.02 µM), and c-Kit (IC50 = 0.5 µM).1,2 It has been shown to inhibit RET autophosphorylation and activation of downstream effectors and to prevent the growth of human thyroid cancer cell lines with activating mutations of RET but not of lines without RET mutations.1 In xenografts of NIH3T3 cells expressing oncogenic RET and of the MTC cell line TT in nude mice, AST-487 dose dependently inhibited tumor growth.1 It also demonstrates antiproliferative effects on primary cells from acute myelocytic leukemia patients and on cell lines expressing FLT3-ITD or FLT3 kinase domain point mutants.1
WARNING This product is not for human or veterinary use.
Technical Information
- NVP-AST-487
- DMF: 20 mg/ml
- DMSO: 30 mg/ml
- DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml
- Ethanol: 20 mg/ml
Shipping & Storage Information
SKU | CAYM-19477-5 |
---|---|
Supplier Part Number | 19477-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/19477m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 630124-46-8 |