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Cayman 4-Methylumbelliferyl- Alphal-Iduronide (Free Acid); Puri
NETA PART: | CAYM-19543-1 |
MFG.PART: | 19543-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate. 4-Methylumbelliferyl-α-L-iduronide is cleaved by α-L-iduronidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. This substrate is used in assays that measure the activity of α-L-iduronidase, which is commonly deficient in a type of lysosomal storage disease called mucopolysaccharidosis.
WARNING This product is not for human or veterinary use.
Technical Information
- 4-Methylumbelliferyl-α-L-Idopyranosiduronic Acid
- 4-MU-α-IdoA
- MU-α-IdoA
- DMF: 20 mg/ml
- DMSO: 5 mg/ml
- Ethanol: 1 mg/ml
- PBS (pH 7.2): 1 mg/ml
Shipping & Storage Information
SKU | CAYM-19543-1 |
---|---|
Supplier Part Number | 19543-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/19543m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CA |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 66966-09-4 |