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Cayman Flavokawain B; Purity- Greater Than Or Equal To 98%; Size-
NETA PART: | CAYM-19652-1 |
MFG.PART: | 19652-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Flavokawain B is a natural chalcone first isolated from extracts of kava roots. It induces apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50s = 32, 48, 6.2, and 3.9 µM for LAPC4, LNCaP, PC-3, and DU145 cells, respectively, treated for 48 hours), with increased expression of the proapoptotic protein Bim. Flavokawain B increases Bim expression and inhibits growth of DU145 xenografts in mice. It also increases Bim expression, promotes apoptosis, and induces cell cycle arrest in uterine leiomyosarcoma cells. However, flavokawain B is hepatotoxic, triggering oxidative stress, inhibiting NF-κB signaling, and activating MAPK pathways, culminating in HepG2 and L-02 cell death (LD50s = 15 and 32 µM, respectively).
WARNING This product is not for human or veterinary use.
Technical Information
- Flavokavain B
- DMF: 30 mg/ml
- DMSO: 50 mg/ml
- Ethanol: 10 mg/ml
Shipping & Storage Information
SKU | CAYM-19652-1 |
---|---|
Supplier Part Number | 19652-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/19652m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 1775-97-9 |