Cayman Pelargonidin (Chloride); Purity- Greater Than Or Equal To

Pelargonidin is an anthocyanidin that has been found in P. granatum and has diverse biological activities.^1,2,3,4 It scavenges superoxide anions in cell-free assays (IC₅₀ = 130 µg/ml) and inhibits hydrogen peroxide-induced lipid peroxidation in rat brain homogenates (IC₅₀ = 85 µM).¹ Pelargonidin (3 mg/kg) reduces serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), hepatocyte apoptosis, and hepatic levels of IL-1β, IL-6, TNF-α, and TGF-β in a mouse model of hepatotoxicity induced by acetaminophen (Item No. 10024).² It increases survival and reduces pulmonary fibrosis and leukocyte infiltration in a mouse model of LPS-induced endotoxemia.³ Pelargonidin (0.04-0.4 mg/kg) reduces serum levels of nitric oxide (NO), TNF-α, and IL-6 and increases renal myeloperoxidase (MPO), superoxide dismutase (SOD), and catalase (CAT) activities, as well as increases survival, in a mouse model of cecal ligation and puncture-induced sepsis.⁴ It also decreases escape latency in the Morris water maze, reduces hippocampal malondialdehyde (MDA) levels, and increases hippocampal acetylcholinesterase (AChE) activity in a rat model of Alzheimers disease induced by amyloid-β 25-35 (Aβ (25-35); Item No. 24155).⁵

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