Cayman Diosmin; Purity- Greater Than Or Equal To 90%; Size- 10 G

Diosmin is a flavonoid that has been found in citrus fruits and has diverse biological activities.^,,,, It inhibits LPS-induced production of prostaglandin E₂ (PGE₂; Item No. ), nitric oxide (NO), IL-12, IL-6, and TNF-α in RAW 264.7 macrophages when used at concentrations ranging from 10 to 50 µM. Diosmin (100 mg/kg) reduces gastric ulcer area and leukocyte invasion in a rat model of ethanol-induced gastric injury. It decreases lung malondialdehyde (MDA) levels, increases lung glutathione (GSH) levels and catalase activity, and reduces fibrosis in a mouse model of paraquat-induced lung injury. Diosmin (50 and 100 mg/kg) increases the time spent in the goal quarter in a spatial memory test and reverses hippocampal dentate gyrus long term potentiation impairments in a rat model of scopolamine-induced cognitive impairment. It also reduces mechanical and thermal hyperalgesia in a rat model of neuropathic pain induced by chronic constriction injury.

WARNING This product is not for human or veterinary use.