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Cayman Paeonol; Purity- Greater Than Or Equal To 98%; Size- 1 G;
NETA PART: | CAYM-19862-1 |
MFG.PART: | 19862-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Anastrozole-d12 is intended for use as an internal standard for the quantification of anastrozole (Item No. ) by GC- or LC-MS. Anastrozole is an aromatase/CYP19A1 inhibitor (IC50 = 15 nM for human placental aromatase/CYP19A1). It is selective for aromatase/CYP19A1 over the cytochrome P450 (CYP) isoforms CYP1A2, CYP2A6, CYP2C9, CYP2D6, and CYP3A (IC50s = 27-650 μM). Anastrozole (0.1 mg/kg) blocks ovulation in mature female rats and androstenedione-stimulated uterine development in pubertal female rats. It inhibits peripheral aromatase/CYP19A1 and reduces plasma estradiol concentrations in male pigtailed monkeys when administered at doses greater than 0.1 mg/kg. Anastrozole (0.5 mg/kg) reduces tumor incidence and the number of tumors by 40 and 57%, respectively, as well as increases latency to tumor appearance in a rat model of premenopausal mammary tumorigenesis. Formulations containing anastrozole have been used in the treatment of breast cancer.
WARNING This product is not for human or veterinary use.
Technical Information
- Anastrol-d12
- Chloroform: Soluble
Shipping & Storage Information
SKU | CAYM-19862-1 |
---|---|
Supplier Part Number | 19862-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/19862m.pdf |
Temperature | 22 |
Refrigerated-Frozen | Ambient |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 552-41-0 |