Cayman Tetrandrine; Purity- Greater Than Or Equal To 98%; Size- 5

Tetrandrine is a bis-benzylisoquinoline alkaloid that has been found in R. stephania roots and has diverse biological activities.^1,2,3,4 It induces autophagy in HeLa, MCF-7, and human foreskin fibroblast (HFF) cells when used at a concentration of 5 µM, an effect that can be reversed by the autophagy inhibitor 3-methyladenine (Item No. 13242).¹ Tetrandrine inhibits PAF-, thrombin-, collagen-, ADP-, or epinephrine-induced aggregation of isolated human platelets.² Priming of mesenchymal stem cells (MSCs) with tetrandrine (5 and 10 µM) reduces TNF-α secretion by RAW 264.7 cells in co-culture.³ Ear skin transplantation of tetrandrine-primed MSCs decreases ear levels of TNF-α in a mouse model of ear skin inflammation. Tetrandrine (1 mg/kg) increases soleus muscle levels of glucose transporter 4 (Glut4) and decreases plasma glucose levels in a rat model of diabetes induced by streptozotocin (Item No. 13104).⁴

WARNING This product is not for human or veterinary use.