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Cayman Hlcl-61 (Hydrochloride); Purity- Greater Than Or Equal To
Cayman Hlcl-61 (Hydrochloride); Purity- Greater Than Or Equal To 98%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$172.00
Your Price
$172.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-19897-10 |
| MFG.PART: | 19897-10 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
HLCL-61 is an inhibitor of protein arginine methyltransferase 5 (PRMT5) that inhibits the growth of multiple acute myeloid leukemia (AML) cell lines and patient-derived tumor samples (IC50s = 7.21-21.46 and 3.98-8.72 μM, respectively).1 It is selective for PRMT5, lacking activity against PRMT1, PRMT4, and PRMT7 in an enzyme assay. HLCL-61 induces myeloid differentiation of THP-1 cells and increases CD11b expression in a dose-dependent manner. It also increases expression of miR-29b mRNA resulting in a 4-fold decrease in FLT3 activity in THP-1 cells expressing an FLT3 luciferase reporter.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
9-ethyl-N-[(2-
CAS Number
1158279-20-9
Molecular Formula
C23H24N2O • HCl
Formula Weight
380.9
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMSO: >1mg/ml
- Ethanol: >1mg/ml
λmax
239, 267, 297 nm
SMILES
COC1=CC=CC=C1CNCC2=CC=C(N(CC)C3=C4C=CC=C3)C4=C2.Cl
InChi Code
InChI=1S/C23H24N2O.ClH/c1-3-25-21-10-6-5-9-19(21)20-14-17(12-13-22(20)25)15-24-16-18-8-4-7-11-23(18)26-2;/h4-14,24H,3,15-16H2,1-2H3;1H
InChi Key
XYAVCNMZZKTEGR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-19897-10 |
|---|---|
| Supplier Part Number | 19897-10 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/19897m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | CN |
| ProductLine | CAYM |
| Qty | 10 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 1158279-20-9 |