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Cayman On-123300; Purity- Greater Than Or Equal To 98%; Size- 25
NETA PART: | CAYM-19902-25 |
MFG.PART: | 19902-25 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
ON-123300 is a multi-kinase inhibitor.1,2 It inhibits ARK5, Cdk4, and Cdk6 (IC50s = 3.87, 9.82, and 4.95 nM, respectively) as well as FYN, PDGFRβ, Abl, and PI3Kδ (IC50s = 11.09, 26, 53.32, and 144 nM, respectively) among others.2 It inhibits proliferation in a panel of 38 cancer cell lines (GI50s = 0.05-5 µM).2 ON-123300 also inhibits proliferation of U87 glioma cells (IC50 = 3.4 µM), decreases phosphorylation of Akt and activates ERK, as well as halts the cell cycle in the G2/M phase and induces apoptosis.1 When used in combination with the EGFR inhibitor gefitinib (Item No. 13166), it synergistically induces cytotoxicity of U87, U87 VIII, and U87 PTEN cells. ON-123300 reduces tumor growth in an MDA-MB-231 mouse xenograft model when administered at a dose of 50 mg/kg every other day.2
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 16 mg/mL
- DMF:PBS(pH7.2) (1:2): 0.3 mg/mL
- DMSO: 10 mg/mL
- Ethanol: 0.25 mg/mL
Shipping & Storage Information
SKU | CAYM-19902-25 |
---|---|
Supplier Part Number | 19902-25 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/19902m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 25 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 1357470-29-1 |