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Cayman Mrt68921; Purity- Greater Than Or Equal To 98%; Size- 1 Mg
NETA PART: | CAYM-19905-1 |
MFG.PART: | 19905-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Gap 19 is a nonapeptide derivative of connexin43 (Cx43) and an inhibitor of Cx43 hemichannels., It suppresses the membrane charge transfer (Qm) in HeLa cells expressing Cx43 (IC50 = ~6.5 µM), as well as Cx43 hemichannel currents in isolated guinea pig cardiomyocytes when used at a concentration of 100 µM. Gap 19 inhibits glutamate-induced ATP release, a marker of Cx43 hemichannel activity, in primary mouse astrocytes. In vivo, Gap 19 (300 µg/kg, i.c.v.) decreases cortical neuronal loss, infarct volume, and the number of errors in a foot fault test in a mouse model of cerebral ischemia and reperfusion injury induced by middle cerebral artery occlusion (MCAO). It also reduces infarct size in a mouse model of myocardial ischemia and reperfusion injury induced by ligation of the left anterior descending (LAD) artery when administered at a dose of 25 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
- KQIEIKKFK
- Water: 2 mg/ml
Shipping & Storage Information
SKU | CAYM-19905-1 |
---|---|
Supplier Part Number | 19905-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/19905m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 1190379-70-4 |