We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Share this :
Print
Cayman Ljh685; Purity- Greater Than Or Equal To 98%; Size- 25 Mg
Cayman Ljh685; Purity- Greater Than Or Equal To 98%; Size- 25 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$456.00
Your Price
$456.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CAYM-19913-25 |
MFG.PART: | 19913-25 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
LJH685 is an inhibitor of p90 ribosomal S6 kinases (RSKs, also known as MAP kinase-activated protein kinases, or MAPKAPKs) that inhibits RSK1, 2, and 3 in vitro with IC50 values of 6, 5, and 4 nM, respectively.1 It is selective for RSKs over a panel of 96 other kinases. LJH685 blocks RSK activity in cells, preventing phosphorylation of y-box-binding protein 1 on Ser102.1 The inhibition of RSK activity correlates with antiproliferative effects in MAPK pathway-dependent cancer cell lines, but only in an anchorage-independent growth setting.1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2,6-difluoro- 4-[4-[4-(4- methyl-1- piperazinyl) phenyl]-3- pyridinyl]- phenol
CAS Number
1627710-50-2
Molecular Formula
C22H21F2N3O
Formula Weight
381.4
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- DMSO:PBS (pH 7.2) (1:7): 0.125 mg/ml
- Ethanol: 2.5 mg/ml
λmax
237, 270, 316 nm
SMILES
CN(CC1)CCN1C(C=C2)=CC=C2C3=CC=NC=C3C4=CC(F)=C(O)C(F)=C4
InChi Code
InChI=1S/C22H21F2N3O/c1-26-8-10-27(11-9-26)17-4-2-15(3-5-17)18-6-7-25-14-19(18)16-12-20(23)22(28)21(24)13-16/h2-7,12-14,28H,8-11H2,1H3
InChi Key
IKUFKDGKRLMXEX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
SKU | CAYM-19913-25 |
---|---|
Supplier Part Number | 19913-25 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/19913m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 25 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 1627710-50-2 |