Cayman Pd-1pd-L1 Inhibitor 1; Purity- Greater Than Or Equal To 98

AY 9944 prevents cholesterol biosynthesis by inhibiting the 7-dehydro cholesterol Δ⁷-reductase (DHCR7) enzyme (IC₅₀ = 13 nM), which interferes with the conversion of 7-dehydro cholesterol (Item No. ) to cholesterol.^, Furthermore, by upregulating the expression of DHCR7, AY 9944 can block Hedgehog signaling at the level of Smoothened or by loss of Suppressor of Fused. AY 9944 inhibition of DHCR7 has been used to recapitulate phenotypes of Smith-Lemli-Opitz syndrome, a disorder brought about by mutations in the DHCR7 gene, in animal models.^, However, AY 9944 is highly teratogenic, producing congenital defects in offspring when fed to pregnant animals.

WARNING This product is not for human or veterinary use.