Cayman Ozanimod; Purity- Greater Than Or Equal To 98%; Size- 25 M

Voacangine is an indole alkaloid that has been found in T. citrifolia, V. africana, V. obtusa, and T. iboga with diverse biological activities.^, It inhibits the growth of M. tuberculosis, M. avium, and M. kansasii with MIC values of 50, >200, and 100 μg/mL, respectively. Voacangine (0.01-100 μM) dose-dependently reduces membrane currents in HEK293 cells expressing the hERG potassium channel and displaces the hERG ligand dofetilide (Item No. ) with a K_i value of 3.9 μM. Voacangine suppresses agonist-induced activation of transient receptor potential (TRP) channels with IC₅₀ values of 50 and 9 μM for activation induced by the TRPV1 agonist capsaicin (Item No. ) and the TRPM8 agonist menthol, respectively. It also activates TRPA1 channels and stimulates calcium influx (IC₅₀ = 8 μM in HEK293 cells expressing TRPA1), an effect that is blocked by the TRPA1 blocker HC-030031 (Item No. ). In vivo, voacangine (2 and 4 μg per egg) inhibits angiogenesis in chick embryo chorioallantoic membranes without apparent cytotoxicity.

WARNING This product is not for human or veterinary use.