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Cayman Cemmec1; Purity- Greater Than Or Equal To 98%; Size- 5 Mg
NETA PART: | CAYM-19956-5 |
MFG.PART: | 19956-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Branebrutinib is a covalent inhibitor of Bruton’s tyrosine kinase (BTK; IC50 = 0.1 nM). It is greater than 5,000-fold selective for BTK over a panel of 240 kinases but does inhibit the additional Tec family kinases Tec, BMX, and TMX (IC50s = 0.9, 1.5, and 5 nM, respectively). Branebrutinib inhibits calcium flux in Ramos B cells induced by B cell receptor (BCR) stimulation (IC50 = 7.2 nM), as well as BCR stimulation-induced proliferation of, and CD86 surface expression in, peripheral B cells (IC50s = 0.04 and 0.3 nM, respectively). It inhibits TNF-α production in human peripheral blood mononuclear cells (PMBCs) induced by Fcγ receptor stimulation (IC50 = 0.3 nM). Branebrutinib (0.5 mg/kg) is completely protective against bone destruction in a mouse model of collagen-induced arthritis. It also reduces proteinuria and glomerular IgG immune complex deposition and increases survival in an NZB/W lupus-prone mouse model.
WARNING This product is not for human or veterinary use.
Technical Information
- BMS-986195
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml
- Ethanol: 1 mg/ml
Shipping & Storage Information
SKU | CAYM-19956-5 |
---|---|
Supplier Part Number | 19956-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/19956m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 440662-09-9 |