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Cayman A-804598; Purity- Greater Than Or Equal To 98%; Size- 50 M
NETA PART: | CAYM-20060-50 |
MFG.PART: | 20060-50 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
A-804598 is a potent and selective competitive antagonist of the purinergic P2X7 receptor, a ligand-gated ion channel, with IC50 values of 9.9 and 10.9 nM in 132N1 cells transfected with the rat or mouse receptor, respectively.1 It inhibits IL-1β release in human THP-1 cells stimulated with LPS and IFN-γ (IC50 = 8.5 nM). A-804598 is selective for P2X7 receptors over other P2X and P2Y receptors at concentrations up to 100 µM and over many G protein-coupled receptors, enzymes, transporters, and ion channels. A-804598 (25 mg/kg) prevents footshock-induced increases in IL-1β mRNA in the paraventricular nucleus of the rat hypothalamus.2
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- DMSO:PBS (pH 7.2) (1:20): 0.05 mg/ml
Shipping & Storage Information
SKU | CAYM-20060-50 |
---|---|
Supplier Part Number | 20060-50 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/20060m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 50 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 1125758-85-1 |