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Cayman K-Ras(G12c) Inhibitor 12; Purity- Greater Than Or Equal To
Cayman K-Ras(G12c) Inhibitor 12; Purity- Greater Than Or Equal To 95%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$145.00
Your Price
$145.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-20118-5 |
| MFG.PART: | 20118-5 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
BI-9627 is an inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1), with IC50 values of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. It is greater than 30-fold selective for NHE1 over NHE2 and is inactive at NHE3 up to 16 μM in a pHi assay. BI-9627 inhibits phenylephrine-induced hypertrophy in neonatal rat cardiomyocytes. It increases recovery of left ventricular developed pressure and inhibits increases in left ventricular end-diastolic pressure (LVEDP) in a Langendorff isolated perfused rat heart model of ischemia-reperfusion injury when used at a concentration of 100 nM. BI-9627 (45 and 150 ppm in the diet) also attenuates decreases in left ventricular end-systolic pressure and increases in LVEDP in coronary artery-ligated rats.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-(1-acetyl-
CAS Number
1204329-34-9
Molecular Formula
C16H19F3N4O2
Formula Weight
356.3
Purity
≥95% (mixture of tautomers)
Formulation
A solid
Solubility
- DMF: 10mg/mL
- DMSO: 20mg/mL
- DMSO:PBS (pH 7.2) (1:7): 0.12mg/mL
λmax
244 nm
SMILES
CC(N(CC1)CCC1C2=CC=C(C(NC(N)=N)=O)C=C2C(F)(F)F)=O
InChi Code
InChI=1S/C16H19F3N4O2/c1-9(24)23-6-4-10(5-7-23)12-3-2-11(14(25)22-15(20)21)8-13(12)16(17,18)19/h2-3,8,10H,4-7H2,1H3,(H4,20,21,22,25)
InChi Key
QMHRLXNEGYTSRV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-20118-5 |
|---|---|
| Supplier Part Number | 20118-5 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/20118m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 5 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 1469337-95-8 |