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Cayman Ph-797804; Purity- Greater Than Or Equal To 98%; Size- 10
Cayman Ph-797804; Purity- Greater Than Or Equal To 98%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$321.00
Your Price
$321.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-20244-10 |
| MFG.PART: | 20244-10 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
PH-797804 is an inhibitor of p38α MAPK with an IC50 value of 26 nM in a cell-free assay.1,2 It is 4-fold more selective for p38α compared to p38β and does not inhibit JNK2 or ERK at concentrations up to 1 µM.1 PH-797804 treatment for 10 days in vivo demonstrates anti-inflammatory activity in chronic inflammatory disease models, significantly reducing both joint inflammation and associated bone loss in streptococcal cell wall-induced arthritis in rats and collagen-induced arthritis in mice.1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-[3-bromo-4-
CAS Number
586379-66-0
Molecular Formula
C22H19BrF2N2O3
Formula Weight
477.3
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 12.5 mg/mL
- DMSO: 14 mg/mL
- DMSO:PBS (pH 7.2)(1:5): 0.16 mg/mL
- Ethanol: 2.5 mg/mL
λmax
219, 309 nm
SMILES
FC1=CC(F)=C(COC2=C(Br)C(N(C3=C(C)C=CC(C(NC)=O)=C3)C(C)=C2)=O)C=C1
InChi Code
InChI=1S/C22H19BrF2N2O3/c1-12-4-5-14(21(28)26-3)9-18(12)27-13(2)8-19(20(23)22(27)29)30-11-15-6-7-16(24)10-17(15)25/h4-10H,11H2,1-3H3,(H,26,28)
InChi Key
KCAJXIDMCNPGHZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-20244-10 |
|---|---|
| Supplier Part Number | 20244-10 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/20244m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | CN |
| ProductLine | CAYM |
| Qty | 10 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 586379-66-0 |