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Cayman Tetrabenazine; Purity- Greater Than Or Equal To 98% (Mixtu
NETA PART: | CAYM-20380-100 |
MFG.PART: | 20380-100 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Tetrabenazine is an inhibitor of vesicular monoamine transporter 2 (VMAT2) that is selective over VMAT1 (Kis = 97 and >20,000 nM, respectively, in a serotonin uptake assay).1 It dose-dependently reduces levels of the monoamines norepinephrine (Item No. 16673), dopamine (Item No. 21992), and serotonin (5-HT; Item No. 14332) in rat brain and has been used to induce depressive-like behavior in animal models.2,3 Tetrabenazine (5 mg/kg) improves performance in balance beam and rotarod tests and prevents decreases in the number of striatal medium spiny neurons (MSNs) in a YAC128 transgenic mouse model of Huntingtons disease.4 Formulations containing tetrabenazine have been used in the treatment of chorea associated with Huntingtons disease.
WARNING This product is not for human or veterinary use.
Technical Information
- NSC 169886
- NSC 172187
- Ro 1-9569
- TBZ
- DMF: 30 mg/ml
- DMF:PBS(pH7.2) (1:2): 0.33 mg/ml
- DMSO: 25 mg/ml
- Ethanol: 10 mg/ml
Shipping & Storage Information
SKU | CAYM-20380-100 |
---|---|
Supplier Part Number | 20380-100 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/20380m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 100 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 58-46-8 |