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Cayman 2,3-Dimethoxy-5-Methyl-P-Benzoquinone; Purity- Greater Tha
Cayman 2,3-Dimethoxy-5-Methyl-P-Benzoquinone; Purity- Greater Than Or Equal To 98%; Size- 10 G; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$243.00
Your Price
$243.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-20504-10 |
| MFG.PART: | 20504-10 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
Oclacitinib is an inhibitor of the JAK family kinases JAK1, JAK2, JAK3, and TYK2 (IC50s = 10, 18, 99, and 84 nM, respectively). It is selective for JAK kinases over a panel of 38 additional kinases at 1 μM. Oclacitinib inhibits LPS-induced increases in IL-12 and TNF-α levels in murine bone marrow-derived dendritic cells (BMDCs) in a concentration-dependent manner. Topical administration of oclacitinib (0.1, 0.25, and 0.5%) reduces scratching behavior and ear edema, as well as decreases levels of IL-1β, IL-4, and IL-6 in ear skin, in a mouse model of allergic dermatitis induced by toluene-2,3-diisocyanate (TDI). Formulations containing oclacitinib have been used in the treatment of pruritus associated with allergic dermatitis and the control of atopic dermatitis in dogs.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
trans-N-methyl-4-
CAS Number
1208319-26-9
Synonyms
- PF-03394197
Molecular Formula
C15H23N5O2S
Formula Weight
337.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 14 mg/ml
- DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml
- DMSO: 12 mg/ml
λmax
217, 286 nm
SMILES
CNS(C[C@@H]1CC[C@@H](N(C2=NC=NC3=C2C=CN3)C)CC1)(=O)=O
InChi Code
InChI=1S/C15H23N5O2S/c1-16-23(21,22)9-11-3-5-12(6-4-11)20(2)15-13-7-8-17-14(13)18-10-19-15/h7-8,10-12,16H,3-6,9H2,1-2H3,(H,17,18,19)/t11-,12-
InChi Key
HJWLJNBZVZDLAQ-HAQNSBGRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-20504-10 |
|---|---|
| Supplier Part Number | 20504-10 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/20504m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | CN |
| ProductLine | CAYM |
| Qty | 10 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 605-94-7 |