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Cayman Pobn; Purity- Greater Than Or Equal To 98%; Size- 1 G
NETA PART: | CAYM-20623-1 |
MFG.PART: | 20623-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
VX-765 is a prodrug form of the caspase-1 inhibitor VRT-043198. VX-765 (50, 100, and 200 mg/kg) inhibits LPS-induced increases in serum IL-1β levels in mice. It also reduces oxazolone-induced ear edema and levels of IL-1β, IL-18, and IFN-γ in ear tissue in an oxazolone-sensitized mouse model of delayed-type hypersensitivity. VX-765 reduces forepaw inflammation in a mouse model of collagen-induced arthritis in a dose-dependent manner. VX-765 (≥50 mg/kg) decreases seizure duration and the number of seizures in a mouse model of acute seizures induced by hippocampal kainic acid injection, as well as delays the onset of seizures when administered at doses of 100 and 200 mg/kg. It also reduces the aggregated duration of epileptic activity in a mouse model of chronic epilepsy.
WARNING This product is not for human or veterinary use.
Technical Information
- Belnacasan
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 30 mg/ml
- Ethanol:PBS (pH 7.2) (1:9): 0.1 mg/ml
Shipping & Storage Information
SKU | CAYM-20623-1 |
---|---|
Supplier Part Number | 20623-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/20623m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 66893-81-0 |