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Cayman 1,5,7-Triazabicyclo[440]Dec-5-Ene; Purity- Greater Than Or
NETA PART: | CAYM-20975-5 |
MFG.PART: | 20975-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
SB-742457 is an orally bioavailable antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 1.4 nM)., SB-742457 (1 μM) also binds to 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors with high affinity. SB-742457 reduces 5-HT6 activation of Gs-mediated cAMP production in a concentration-dependent manner with an EC50 value of 21 nM in NG108-15 neuroblastoma cells. In vivo, SB-742457 (1.5 mg/kg, p.o.) reverses deficits in novel object recognition induced by scopolamine (Item No. ) in rats. It also reverses age-induced impairments in spatial memory acquisition and retention in rats in the Morris water maze. SB-742457 (3.0 mg/kg, i.p.) reduces the number of licking bouts by 24% compared with control in rats trained to lick a glucose solution, indicating a role in satiety and obesity management.
WARNING This product is not for human or veterinary use.
Technical Information
- GSK742457
- DMF: 5 mg/ml
- DMSO: 5 mg/ml
- Ethanol: 0.1 mg/ml
Shipping & Storage Information
SKU | CAYM-20975-5 |
---|---|
Supplier Part Number | 20975-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/20975m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 5807-14-7 |