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Cayman Stearamide; Purity- Greater Than Or Equal To 98%; Size- 50
Cayman Stearamide; Purity- Greater Than Or Equal To 98%; Size- 500 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$109.00
Your Price
$109.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CAYM-21087-500 |
MFG.PART: | 21087-500 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
RKI-1447 is an inhibitor of the Rho-associated kinases ROCK1 and 2 (IC50s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase. In cancer cells, RKI-1447 at a concentration of 100 nM has been found to suppress the activation of ROCK substrates myosin light chain (MLC)-2 and the MLC phosphatase PP1 regulatory subunit MYPT1 without effect on the phosphorylation of Akt, MEK, or S6 kinase. Furthermore, it can prevent ROCK-mediated migration, invasion, and anchorage-independent growth of MDA-MB-231 breast cancer cells (IC50 = 709 nM).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[(3-hydroxy phenyl)methyl]- N-[4-(4- pyridinyl)-2- thiazolyl]- urea
CAS Number
1342278-01-6
Molecular Formula
C16H14N4O2S
Formula Weight
326.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
λmax
228, 265 nm
SMILES
OC1=CC(CNC(NC2=NC(C3=CC=NC=C3)=CS2)=O)=CC=C1
InChi Code
InChI=1S/C16H14N4O2S/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12/h1-8,10,21H,9H2,(H2,18,19,20,22)
InChi Key
GDVRVPIXWXOKQO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
SKU | CAYM-21087-500 |
---|---|
Supplier Part Number | 21087-500 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/21087m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 500 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 124-26-5 |