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Cayman Tnp; Purity- Greater Than Or Equal To 98%; Size- 1 Mg
NETA PART: | CAYM-21189-1 |
MFG.PART: | 21189-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Pleckstrin homology (PH) domains all contain a seven-standard b-sandwich that allows binding to various species of phosphatidylinositol (PtdIns) phosphates. Most PH domains bind to PtdIns phosphates with weak affinity and low specificity. However, a small subclass binds specifically and with high-affinity for certain PtdIns phosphates. PtdIns-(4,5)-P2 Binding Protein (GST-tagged) contains a highly specific PH domain that recognizes and binds PtdIns-(4,5)-P2 (see Figure 1). PtdIns phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals., PtdIns-(4,5)-P2 can be phosphorylated by phosphoinositide (PI)-3-kinase to make PtdIns-(3,4,5)-P3 which initiates an intricate signaling cascade that has been implicated in cancer PtdIns-(4,5)-P2 binding protein can be used in in vitro assays for the detection of PtdIns-(4,5)-
WARNING This product is not for human or veterinary use.
Technical Information
- Phosphatidylinositol-4,5-diphosphate
- PI(4,5)-P2
- PI(4,5)P2 Binding Protein
- PIP2
- PIP2[4,5] Binding Protein
- PLC-δ1-PH Domain
Shipping & Storage Information
SKU | CAYM-21189-1 |
---|---|
Supplier Part Number | 21189-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/21189m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 519178-28-0 |