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Cayman Cromolyn (Sodium Salt Hydrate); Purity- Greater Than Or Eq
NETA PART: | CAYM-21379-10 |
MFG.PART: | 21379-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
HLM006474 is a non-selective inhibitor of the transcription factor E2F (IC50 = 29.8 µM for E2F4). It inhibits DNA binding to E2F1, E2F2, and E2F4 in A375 melanoma cells when used at a concentration of 40 µM. HLM006474 (40 µM) decreases protein levels of E2F4 and cyclin D3 and induces apoptosis in A375 cells. It also induces apoptosis in MDA-MB-231, but not MCF-7, cells and inhibits the growth of cancer cells in a panel of 17 lung cancer cell lines (IC50s = 15.5-75.1 µM)., HLM006474 reduces tumor growth in retinoblastoma-prone Chx10Cre;Rbfl/fl;p107-/- mice and in an A375 mouse xenograft model when administered at a dose of 100 mg/kg and 2 mg per mouse, respectively.,
WARNING This product is not for human or veterinary use.
Technical Information
- DMSO: soluble
Shipping & Storage Information
SKU | CAYM-21379-10 |
---|---|
Supplier Part Number | 21379-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/21379m.pdf |
Temperature | 22 |
Refrigerated-Frozen | Ambient |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |