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Cayman Manzamine A; Purity- Greater Than Or Equal To 98%; Size- 5
NETA PART: | CAYM-21444-500 |
MFG.PART: | 21444-500 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Zatebradine is a bradycardic compound that blocks hyperpolarization-activated inward current (If) through cyclic nucleotide-gated cation (HCN) channels in sinoatrial node cells (IC50s = 1.83, 2.21, 1.9, and 1.88 µM, respectively for HCN1-4 in vitro)., Additionally, it can block voltage-gated outward K+ (IK) currents and related neuronal hyperpolarization-activated inward current (Ih) channels, but exhibits little or no activity for L-type Ca2+ (ICa) currents., When assessed through telemetric ECG recording in mice, zatebradine reduced heart rate from 600 to 200 beats per minute with an ED50 value of 1.8 mg/kg and induced increasing arrhythmia at concentrations >10 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
- UL-FS 49
- DMF: 25 mg/ml
- DMSO: 20 mg/ml
- Ethanol: 1 mg/ml
- PBS (pH 7.2): 10 mg/ml
Shipping & Storage Information
SKU | CAYM-21444-500 |
---|---|
Supplier Part Number | 21444-500 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/21444m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 500 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 104196-68-1 |