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Cayman Ly2606368; Purity- Greater Than Or Equal To 98%; Size- 10
Cayman Ly2606368; Purity- Greater Than Or Equal To 98%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$799.00
Your Price
$799.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CAYM-21490-10 |
MFG.PART: | 21490-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
LY2606368 is a checkpoint kinase 1 (Chk1) inhibitor with a Ki value of 0.9 nM against the purified target and IC50 values of <13 nM in a viability study of multiple colorectal cancer cell lines.1,2 Inhibition of Chk1 causes double-strand DNA breakage in cells leading to an excessive cell damage burden and subsequent cell death.1,2 In vitro, LY2606368 inhibits the doxorubicin-activated G2/M checkpoint in p53-deficient HeLa cells with an EC50 value of 9 nM.1 LY2606368, at 25 nM, also significantly induces apoptosis and inhibits colony formation in AGS and MKN1 gastric cancer cells.3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-[[5-[2-(3- aminopropoxy) -6-methoxy phenyl]-1H- pyrazol-3-yl] amino]-2- pyrazinecarbo nitrile
CAS Number
1234015-52-1
Synonyms
- Prexasertib
Molecular Formula
C18H19N7O2
Formula Weight
365.4
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
λmax
214, 295 nm
SMILES
NCCCOC1=C(C2=CC(N([H])C3=NC=C(C#N)N=C3)=NN2[H])C(OC)=CC=C1
InChi Code
InChI=1S/C18H19N7O2/c1-26-14-4-2-5-15(27-7-3-6-19)18(14)13-8-16(25-24-13)23-17-11-21-12(9-20)10-22-17/h2,4-5,8,10-11H,3,6-7,19H2,1H3,(H2,22,23,24,25)
InChi Key
DOTGPNHGTYJDEP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
SKU | CAYM-21490-10 |
---|---|
Supplier Part Number | 21490-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/21490m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 1234015-52-1 |