We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman Lly-283; Purity- Greater Than Or Equal To 98%; Size- 25 Mg
NETA PART: | CAYM-21596-25 |
MFG.PART: | 21596-25 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
GI 254023X is an inhibitor of the metalloproteinase-disintegrin ADAM10 (IC50 = 5.3 nM). It is selective for ADAM10 over ADAM17, matrix metalloproteinase-1 (MMP-1), and MMP-3 (IC50s = 541, 108, and 187 nM, respectively), but also inhibits MMP-9 and MMP-13 (IC50s = 2.5 and 1.1 nM, respectively). GI 254023X inhibits constitutive shedding of CX3CL1, but not shedding induced by phorbol 12-myristate 13-acetate (PMA; Item No. ), in COS-7 cells transfected with human chemokines (IC50s = 0.4 and >10 μM, respectively). It also inhibits constitutive, but not PMA-induced, secretion of the IL-6 receptor (IL-6R) from THP-1 macrophages (IC50s = 1.8 and >10 μM, respectively). GX 254023X (1 μM) decreases shedding of low density lipoprotein receptor-related protein 1 (LRP1) induced by amyloid-β (1-42) (Aβ42; Item No. ) in human brain microvessel endothelial cells (HBMECs) and increases Aβ42 transit across an in vitro blood brain barrier model in a concentration-dependent manner. In vivo, GI 254023X (200 mg/kg) reduces brain LRP1 shedding and increases plasma levels of Aβ40 in a mouse model of Alzheimers disease.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name | (αR)-N-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-α-[(1S)-1-(formylhydroxyamino)ethyl]-benzenepentanamide |
CAS Number | 260264-93-5 |
Synonyms |
|
Molecular Formula | C21H33N3O4 |
Formula Weight | 391.5 |
Purity | ≥98% |
Formulation | A crystalline solid |
Solubility |
|
SMILES | C[C@H](N(C=O)O)[C@H](C(N[C@@H](C(C)(C)C)C(NC)=O)=O)CCCC1=CC=CC=C1 |
InChi Code | InChI=1S/C21H33N3O4/c1-15(24(28)14-25)17(13-9-12-16-10-7-6-8-11-16)19(26)23-18(20(27)22-5)21(2,3)4/h6-8,10-11,14-15,17-18,28H,9,12-13H2,1-5H3,(H,22,27)(H,23,26)/t15-,17+,18+/m0/s1 |
InChi Key | GHVMTHKJUAOZJP-CGTJXYLNSA-N |
Storage | -20°C |
Shipping | Room Temperature in continental US; may vary elsewhere |
Stability | ≥ 4 years |
SKU | CAYM-21596-25 |
---|---|
Supplier Part Number | 21596-25 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/21596m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 2040291-27-6 |