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Cayman Propylphosphonic Acid; Purity- Greater Than Or Equal To 98
![](https://netam2po.netascientific.info/media/skin/seal2.png)
![](https://netam2po.netascientific.info/media/skin/seal.png)
NETA PART: | CAYM-21702-10 |
MFG.PART: | 21702-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
HLM006474 is a non-selective inhibitor of the transcription factor E2F (IC50 = 29.8 µM for E2F4). It inhibits DNA binding to E2F1, E2F2, and E2F4 in A375 melanoma cells when used at a concentration of 40 µM. HLM006474 (40 µM) decreases protein levels of E2F4 and cyclin D3 and induces apoptosis in A375 cells. It also induces apoptosis in MDA-MB-231, but not MCF-7, cells and inhibits the growth of cancer cells in a panel of 17 lung cancer cell lines (IC50s = 15.5-75.1 µM)., HLM006474 reduces tumor growth in retinoblastoma-prone Chx10Cre;Rbfl/fl;p107-/- mice and in an A375 mouse xenograft model when administered at a dose of 100 mg/kg and 2 mg per mouse, respectively.,
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name | 7-[(4-ethoxy-3-methylphenyl)(2-pyridinylamino)methyl]-2-methyl-8-quinolinol |
CAS Number | 353519-63-8 |
Molecular Formula | C25H25N3O2 |
Formula Weight | 399.5 |
Purity | ≥95% |
Formulation | A solid |
Solubility |
|
λmax | 206, 250, 306 nm |
SMILES | CCOC1=CC=C(C(NC2=NC=CC=C2)C3=CC=C(C=CC(C)=N4)C4=C3O)C=C1C |
InChi Code | InChI=1S/C25H25N3O2/c1-4-30-21-13-11-19(15-16(21)2)23(28-22-7-5-6-14-26-22)20-12-10-18-9-8-17(3)27-24(18)25(20)29/h5-15,23,29H,4H2,1-3H3,(H,26,28) |
InChi Key | CYNZBLNMIJNBSF-UHFFFAOYSA-N |
Storage | -20°C |
Shipping | Room Temperature in continental US; may vary elsewhere |
Stability | ≥ 4 years |
SKU | CAYM-21702-10 |
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Supplier Part Number | 21702-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/21702m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 4672-38-2 |