Cayman Mpt0b014; Size- 25 Mg

MPT0B014 is an inhibitor of tubulin polymerization.¹ It inhibits proliferation of A549, H1299, and H226 human non-small cell lung cancer (NSCLC) cells (IC₅₀s = 0.041, 0.046, and 0.041 µM, respectively), as well as adriamycin-resistant NCI/ADR cells that overexpress P-glycoprotein (IC₅₀ = ~0.03 µM). MPT0B014 (0.3 µM) induces cell cycle arrest at the G₂/M phase and apoptosis in A549 cells. It reduces tumor growth in an A549 mouse xenograft model when administered in combination with the EGFR tyrosine kinase inhibitor erlotinib (Item No. 10483).

WARNING This product is not for human or veterinary use.