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Cayman 4-Piperidone (Hydrochloride Hydrate); Purity- Greater Than
NETA PART: | CAYM-21961-10 |
MFG.PART: | 21961-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
(R)-AM1241 binds to cannabinoid (CB) receptors and has greater than 100-fold selectivity for the CB2 over the CB1 receptor (Kis = 15 and 5,000 nM, respectively, in a membrane assay using human receptors). (R)-AM1241 acts as an agonist at human CB2 receptors (EC50 = 118 nM) but an inverse agonist at rat and mouse CB2 receptors (EC50s = 315 and 341 nM, respectively). Similar to the racemate AM1241 (Item No. ), (R)-AM1241 produces antinociception to thermal, but not mechanical, pain in rats. The pain-reducing effect of (R)-AM1241 is blocked by the CB2-specific inhibitor SR 144528 (Item No. ) but not by either the CB1-selective inhibitor rimonabant (Item No. ) or the opioid receptor blocker naloxone (Item No. | ).
WARNING This product is not for human or veterinary use.
Technical Information
- (+)-
AM1241
- DMF: 25 mg/ml
- DMF:PBS(pH7.2) (1:2): 0.3 mg/ml
- DMSO: 10 mg/ml
- Ethanol: 5 mg/ml
Shipping & Storage Information
SKU | CAYM-21961-10 |
---|---|
Supplier Part Number | 21961-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/21961m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 40064-34-4 |