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Cayman Mpi-0479605; Purity- Greater Than Or Equal To 98%; Size- 1
NETA PART: | CAYM-22136-1 |
MFG.PART: | 22136-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
MPI-0479605 is a potent and ATP-competitive inhibitor of the mitotic kinase MPS1 (IC50 = 1.8 nM). It is selective for MPS1 over a panel of 79 kinases at a concentration of 500 nM. MPI-0479605 induces time-dependent degradation of cyclin B and securin and decreases phosphorylation of BUBR1 resulting in failed cytokinesis in HeLa cells arrested by nocodazole (Item No. ). It also causes misalignment of chromosomes at the anaphase plate and aneuploidy in A549 cells and slows cell cycle progression of HCT116 and COLO 205 cells irrespective of p53 activity. MPI-0479605 (30-150 mg/kg) reduces tumor volume in an HCT116 mouse colon cancer xenograft model in a dose-dependent manner.
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 1 mg/ml
- DMSO: 1.25 mg/ml
- DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
Shipping & Storage Information
SKU | CAYM-22136-1 |
---|---|
Supplier Part Number | 22136-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/22136m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 1246529-32-7 |