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Cayman Aloperine; Purity- Greater Than Or Equal To 95%; Size- 500
NETA PART: | CAYM-22259-500 |
MFG.PART: | 22259-500 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Aloperine is an alkaloid found in the roots of S. flavescens with diverse biological activities including antiviral, anticancer, antioxidant, and anti-inflammatory actions.1,2,3,4 It inhibits HIV-1 replication and envelope-mediated cell-cell fusion (EC50s = 1.75 and 1.2 μM, respectively) at concentrations well below the cytotoxic concentration (CC50) of >86.5 μM in vitro.1 Aloperine inhibits the growth of HL-60, U937, and K562 leukemia cell lines with IC50 values of 40, 270, and 360 μM, respectively.2 Administration of aloperine, at a dose of 60 mg/kg, reduces NOX2, NOX4, superoxide dismutase, and glutathione peroxidase expression in lungs in a rat model of pulmonary hypertension.3 Topical administration of aloperine reduces ear swelling, ear erythema, and production of inflammatory cytokines TNF-α, IL-1β, and IL-6 in a mouse model of allergic contact dermatitis.4
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 0.2 mg/ml
- DMSO: 0.125 mg/ml
- Ethanol: 20 mg/ml
- Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
Shipping & Storage Information
SKU | CAYM-22259-500 |
---|---|
Supplier Part Number | 22259-500 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/22259m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 500 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 56293-29-9 |