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Cayman Quinidine N-Oxide; Purity- Greater Than Or Equal To 95%; S
Cayman Quinidine N-Oxide; Purity- Greater Than Or Equal To 95%; Size- 500 Micrograms; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$77.00
Your Price
$77.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-22381-500 |
| MFG.PART: | 22381-500 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
HNHA is a cell-permeable inhibitor of histone deacetylase (HDAC) activity (IC50 = 100 nM). In human fibrosarcoma HT1080 cells, it induces histone hyperacetylation and p21 transcription with concomitant inhibition of cell cycle progression (IC50 ~7.5 μM). HNHA is at least as effective as SAHA in inhibiting tumor growth in a murine xenograph model in vivo. HNHA also blocks the growth of human umbilical vein endothelial cells (HUVECs) and prevents tube formation and migration of HUVECs in response to vascular endothelial growth factor (VEGF). It also blocks retinal neovascularization and choroidal angiogenesis in mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-hydroxy-7-
CAS Number
926908-04-5
Synonyms
- Histone Deacetylase Inhibitor VI
Molecular Formula
C17H21NO2S
Formula Weight
303.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
- Ethanol: 20 mg/ml
λmax
218, 254, 284 nm
SMILES
c1ccc2c(c1)cc(cc2)SCCCCCCC(NO)=O
InChi Code
InChI=1S/C17H21NO2S/c19-17(18-20)9-3-1-2-6-12-21-16-11-10-14-7-4-5-8-15(14)13-16/h4-5,7-8,10-11,13,20H,1-3,6,9,12H2,(H,18,19)
InChi Key
KPNNXHVGOKRBEF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-22381-500 |
|---|---|
| Supplier Part Number | 22381-500 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/22381m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | CA |
| ProductLine | CAYM |
| Qty | 500 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 70116-00-6 |