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Cayman Carfilzomib Impurity 13 (Hydrochloride); Purity- Greater T
Cayman Carfilzomib Impurity 13 (Hydrochloride); Purity- Greater Than Or Equal To 100%; Size- 500 Micrograms; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$171.00
Your Price
$171.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-22385-500 |
| MFG.PART: | 22385-500 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
8-bromo Cyclic AMP is an activator of protein kinase A (PKA) with a half-maximal activation (Ka) value of 0.05 µM. It is selective for PKA over cGMP-dependent protein kinase (PKG; Ka = 5.8 µM) and is more resistant to hydrolysis by phosphodiesterases (PDEs) compared with cAMP (Item No. )., 8-bromo Cyclic AMP inhibits the proliferation of HL-60 leukemia cells (IC50 = 18 µM after six days). It induces relaxation of isolated rabbit carotid or renal arterial rings precontracted with phenylephrine when used at concentrations ranging from 10 to 300 µM. Intradermal administration of 8-bromo cyclic AMP (10 nmol/site) prevents scratching and increases in cutaneous leukotriene B4 (LTB4) production induced by the proteinase-activated receptor 2 (PAR2) agonist SLIGRL-NH2 (Item No. ) in mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
8-bromo-
CAS Number
23583-48-4
Synonyms
- 8-Bromoadenosine 3,5-cyclic monophosphate
- 8-bromo cAMP
- NSC 171719
Molecular Formula
C10H11BrN5O6P
Formula Weight
408.1
Purity
≥95%
Formulation
A crystalline solid
Solubility
- PBS (pH 7.2): 3 mg/ml
λmax
213, 263 nm
SMILES
OP1(OC[C@]2([H])[C@@]([C@@H](O)[C@H](N3C(N=CN=C4N)=C4N=C3Br)O2)([H])O1)=O
InChi Code
InChI=1S/C10H11BrN5O6P/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14)/t3-,5-,6-,9-/m1/s1
InChi Key
DVKQVRZMKBDMDH-UUOKFMHZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-22385-500 |
|---|---|
| Supplier Part Number | 22385-500 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/22385m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | CA |
| ProductLine | CAYM |
| Qty | 500 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |