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Cayman Lcl-161; Purity- Greater Than Or Equal To 98%; Size- 10 Mg
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![](https://netam2po.netascientific.info/media/skin/seal.png)
NETA PART: | CAYM-22420-10 |
MFG.PART: | 22420-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
LCL-161 is a small molecule Smac mimetic that inhibits multiple inhibitor of apoptosis (IAP) family proteins. As a single agent, LCL-161 inhibits growth of FLT3-ITD-expressing leukemia cells via induction of apoptosis with IC50 values ranging from 0.5-4 μM. In vivo, LCL-161 enhances growth inhibition driven by PKC 412 (Item No. ) in a mouse Ba/F3-FLT3-ITD-luc+ leukemia xenograft model. It exhibits additive effects with the chemotherapeutic agents doxorubicin (Item No. ) and cytarabine (Item No. ). LCL-161 also inhibits growth of nilotinib-resistant leukemia cell lines and exhibits synergy with nilotinib (Item No. ) in a Bcr-Abl expressing, 32D.p20-luc+ leukemia mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
- NVP-LCL161
- DMF: 30 mg/ml
- DMSO: 20 mg/ml
- Ethanol: 20 mg/ml
Shipping & Storage Information
SKU | CAYM-22420-10 |
---|---|
Supplier Part Number | 22420-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/22420m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 1005342-46-0 |