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Cayman 11-Deoxy Corticosterone; Purity- Greater Than Or Equal To
NETA PART: | CAYM-22916-50 |
MFG.PART: | 22916-50 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
11-deoxy Corticosterone (DOC) is an endogenous mineralocorticoid synthesized in the zona fasciculata and zona glomerulosa of the adrenal gland.1 It is a metabolite of progesterone (Item No. 15876) and precursor to aldosterone (Item No. 15273) and corticosterone (Item No. 16063).2 DOC is metabolized to the neuroactive compound (3α,5α)-2,21-dihydroxypregnan-20-one (THDOC), which positively modulates GABAA receptors and produces effects similar to barbiturates in rats.3 Injections of naloxone (Item Nos. 15594 | ISO60191) and corticotropin-releasing hormone (CRH) increase, while dexamethasone decreases, DOC in cynomolgus monkeys.1 DOC levels are increased 3.4-fold in obese and diabetic mice.2
WARNING This product is not for human or veterinary use.
Technical Information
- DOC
- NSC 11319
- 21-hydroxy Progesterone
- DMF: 25 mg/ml
- DMSO: 25 mg/ml
- Ethanol: 25 mg/ml
- Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
Shipping & Storage Information
SKU | CAYM-22916-50 |
---|---|
Supplier Part Number | 22916-50 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/22916m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 50 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 64-85-7 |