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Cayman Sbc-110736; Size- 10 Mg
Cayman Sbc-110736; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$231.00
Your Price
$231.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-23103-10 |
| MFG.PART: | 23103-10 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
Protectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; Item No. ). DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to protectin D1 enzymatically. Protectin D1 increases phagocytosis of apoptotic polymorphonuclear leukocytes (PMNs) by macrophages in a non-phlogistic manner and is generated in vitro during macrophage-apoptotic interactions. It enhances phagocytosis in mice after 24 hours, but not at the initiation or peak of inflammation. It also decreases PMN infiltration in a zymosan-induced mouse model of inflammation when administered at a dose of 300 ng per animal. Protectin D1 (200 µg, i.v.) inhibits increases in neutrophil counts in bronchoalveolar fluid (BALF) and lung myeloperoxidase activity in a mouse model of pulmonary injury and inflammation induced by intratracheal LPS instillation. It also decreases pulmonary edema and promotes neutrophil apoptosis in BALF.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
10R,17S-
CAS Number
660430-03-5
Synonyms
- Neuroprotectin D1
- NPD1
- PD1
Molecular Formula
C22H32O4
Formula Weight
360.5
Purity
≥98%
Formulation
A solution in ethanol
Solubility
- DMF: 50 mg/ml
- DMSO: 50 mg/ml
- Ethanol: 50 mg/ml
- PBS (pH 7.2): 0.1 mg/ml
λmax
272, 283 nm
SMILES
CC/C=C\C[C@H](O)/C=C\C=C\C=C\[C@H](O)C/C=C\C/C=C\CCC(O)=O
InChi Code
InChI=1S/C22H32O4/c1-2-3-10-15-20(23)17-12-8-9-13-18-21(24)16-11-6-4-5-7-14-19-22(25)26/h3,5-13,17-18,20-21,23-24H,2,4,14-16,19H2,1H3,(H,25,26)/b7-5-,9-8+,10-3-,11-6-,17-12-,18-13+/t20-,21+/m0/s1
InChi Key
CRDZYJSQHCXHEG-SFVBTVKNSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Stability
≥ 1 year
| SKU | CAYM-23103-10 |
|---|---|
| Supplier Part Number | 23103-10 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/23103m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | CN |
| ProductLine | CAYM |
| Qty | 10 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 1629166-02-4 |