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Cayman Cathepsin L Inhibitor; Purity- Greater Than Or Equal To 95
NETA PART: | CAYM-23249-10 |
MFG.PART: | 23249-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Manzamine A is a β-carboline alkaloid with diverse activities that has been found in marine sponges, including X. ashmorica. It is an inhibitor of glycogen synthase kinase 3β (GSK3β) and cyclin-dependent kinase 5 (CDK5; IC50s = 10.2 and 1.5 μM, respectively). It inhibits the growth of L5178y mouse lymphoma cells with an ED50 value of 1.8 μg/mL. In an agar diffusion assay, manzamine A inhibits the growth of B. subtilis and S. aureus, but not E. coli bacteria. It reduces the reverse transcriptase (RT) activity in supernatant from HIV-1-infected peripheral blood mononuclear cells (PBMCs; EC50 = 4.2 μM). In vivo, manzamine A (100 μmol/kg, i.p.) has antimalarial activity and reduces the amount of P. berghei in infected mice by over 90% relative to the control.
WARNING This product is not for human or veterinary use.
Technical Information
- Keramamine A
- DMSO: Soluble
- Ethanol: Soluble
- Methanol: Soluble
Shipping & Storage Information
SKU | CAYM-23249-10 |
---|---|
Supplier Part Number | 23249-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/23249m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 167498-29-5 |