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Cayman 7-Oxo Staurosporine; Purity- Greater Than Or Equal To 98%
Cayman 7-Oxo Staurosporine; Purity- Greater Than Or Equal To 98%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$1,270.50
Your Price
$1,270.50
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-23346-5 |
| MFG.PART: | 23346-5 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
Platelet-type 12-lipoxygenase (12-LO; Item No. ) catalyzes the formation of 12-HpETE (Item No. ) from arachidonic acid (Item No. ). It has been found to be expressed in various tumor cells as well as pancreatic islets and can be activated by inflammatory cytokines. It has also been implicated in the modulation of hemostasis and thrombosis through its role in regulating platelet function. CAY10698 is an inhibitor of 12-LO with an IC50 value of 5.1 µM. It demonstrates greatly reduced potency for 15-LO-1, 15-LO-2, and 5-LO (IC50s = >50, >40, and >200 µM. The scaffold of this compound has been subjected to medicinal chemistry optimization and biological characterization for development of potential 12-LO inhibitors.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[[(2-hydroxy-3-
CAS Number
684236-01-9
Molecular Formula
C17H17N3O4S2
Formula Weight
391.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 25 mg/ml
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml
- DMSO: 20 mg/ml
- Ethanol: 0.5 mg/ml
SMILES
COC1=C(O)C(CNC2=CC=C(S(NC3=NC=CS3)(=O)=O)C=C2)=CC=C1
InChi Code
InChI=1S/C17H17N3O4S2/c1-24-15-4-2-3-12(16(15)21)11-19-13-5-7-14(8-6-13)26(22,23)20-17-18-9-10-25-17/h2-10,19,21H,11H2,1H3,(H,18,20)
InChi Key
CENSVXZQMJBVHY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-23346-5 |
|---|---|
| Supplier Part Number | 23346-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/23346m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | AU |
| ProductLine | CAYM |
| Qty | 5 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 125035-83-8 |