We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman Fosfomycin Trometamol; Purity- Greater Than Or Equal To 98
NETA PART: | CAYM-23632-25 |
MFG.PART: | 23632-25 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Retinoic acid-inducible gene I (RIG-I), also known as DDX58, is a cytosolic DExD/H-box RNA helicase and an immune sensing receptor encoded by DDX58 in humans. It is composed of a C-terminal repressor domain, a central RNA helicase domain, and two N-terminal caspase recruitment domains (CARDs)., Following recognition of viral dsRNA by the C-terminal and helicase domains, the helicase domain induces an ATP-dependent conformational change, allowing for interaction of the CARD domains with mitochondrial antiviral-signaling protein (MAVS) and induction of a type I interferon (IFN) response.,, A single amino acid substitution of phenylalanine for cysteine at position 268 in the RIG-I helicase domain (RIG-IC268F) leads to enhanced NF-κB activity and expression of IFN-β in basal and poly (I:C)-stimulated cells. Overexpression of RIG-IC268F in human trabecular meshwork (HTM) cells induces cell death and is positively correlated with glaucoma, a core symptom in the type I interferonopathy atypical Singleton-Merten syndrome.
WARNING This product is not for human or veterinary use.
Technical Information
- DEAD Box Protein 58
- Probable ATP-dependent RNA Helicase DDX58
- Retinoic Acid-inducible Gene 1 Protein
Shipping & Storage Information
SKU | CAYM-23632-25 |
---|---|
Supplier Part Number | 23632-25 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/23632m.pdf |
Temperature | 4 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CA |
ProductLine | CAYM |
Qty | 25 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 78964-85-9 |