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Cayman Histrelin (Acetate); Purity- Greater Than Or Equal To 98%
Cayman Histrelin (Acetate); Purity- Greater Than Or Equal To 98%; Size- 1 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$97.00
Your Price
$97.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-23663-1 |
| MFG.PART: | 23663-1 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
Histrelin is a synthetic gonadotropin-releasing hormone (GNRH) agonist that binds to the GNRH receptor (GNRHR; Ki = 0.2 nM in CHO cells expressing the human receptor). It stimulates release of oxytocin (Item No. ) and vasopressin ex vivo from the isolated rat hypothalamo-neurohypophysial system at a concentration of 100 nM., In vivo, the initial dose of histrelin (100 μg) stimulates acute increases in luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone serum levels (50-, 2.5-, and 15-fold, respectively), while chronic treatment leads to 95% decreases in LH and FSH responses in rhesus monkeys. Formulations containing histrelin have been used in the treatment of advanced prostate cancer and central precocious puberty.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-[1-(phenyl
CAS Number
220810-26-4
Synonyms
- [Des-Gly10,D-His(Bzl)6]-LHRHethyl amide
- [Des-Gly10,D-His(Bzl)6,Pro-NHEt9]-LHRH
- [(ImBzl)-d-His6,Pro9-NET]-LHRH
Molecular Formula
C66H86N18O12 • XC2H4O2
Formula Weight
1323.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 0.25 mg/ml
- PBS (pH 7.2): 10 mg/ml
λmax
281 nm
SMILES
O=C([C@@H]1CCC(N1)=O)N[C@@H](CC2=CNC=N2)C(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@@H](CO)C(N[C@@H](CC5=CC=C(O)C=C5)C(N[C@H](CC6=CN(CC7=CC=CC=C7)C=N6)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N8CCC[C@H]8C(NCC)=O)=O)=O)=O)=O)=O)=O)=O.OC(C)=O
InChi Code
InChI=1S/C66H86N18O12.C2H4O2/c1-4-70-64(95)55-17-11-25-84(55)65(96)48(16-10-24-71-66(67)68)76-58(89)49(26-38(2)3)77-62(93)53(30-43-34-83(37-74-43)33-40-12-6-5-7-13-40)81-59(90)50(27-39-18-20-44(86)21-19-39)78-63(94)54(35-85)82-60(91)51(28-41-31-72-46-15-9-8-14-45(41)46)79-61(92)52(29-42-32-69-36-73-42)80-57(88)47-22-23-56(87)75-47;1-2(3)4/h5-9,12-15,18-21,31-32,34,36-38,47-55,72,85-86H,4,10-11,16-17,22-30,33,35H2,1-3H3,(H,69,73)(H,70,95)(H,75,87)(H,76,89)(H,77,93)(H,78,94)(H,79,92)(H,80,88)(H,81
InChi Key
OWAUGAMNPZHEOJ-YKZVIGSYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-23663-1 |
|---|---|
| Supplier Part Number | 23663-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/23663m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | CN |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 220810-26-4 |