We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman Pralidoxime (Chloride); Purity- Greater Than Or Equal To 9
NETA PART: | CAYM-23666-1 |
MFG.PART: | 23666-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Pralidoxime reactivates acetylcholinesterase (AChE) that has been deactivated by binding of organophosphates to its esteratic site. Pralidoxime binds to the anionic site of AChE and displaces the phosphate from the esteratic site through formation of phosphate-pralidoxime conjugates. It reactivates paraoxon- and diisopropyl fluorophosphate-inactivated human red blood cell (RBC) AChE with IC50 shifts of 0.3 and 0.8 nM per μM of pralidoxime, respectively., At a concentration of 10 μM, it reactivates human RBC AChE that has been inactivated by chlorpyrifos (Item No. ), diazinon (Item No. ), and malathion (Item No. ) by 17, 61, and 36%, respectively. Pralidoxime binds to sarin-bound hAChE (Kd = 25.72 μM) and inhibits sarin-induced AChE deactivation (IC50 = 1.21 mM) in hemoglobin-free erythrocyte ghosts. Formulations containing pralidoxime have been used to treat organophosphate poisoning.
WARNING This product is not for human or veterinary use.
Technical Information
- 2-PAM
- DMSO: 1 mg/ml
- PBS (pH 7.2): 10 mg/ml
Shipping & Storage Information
SKU | CAYM-23666-1 |
---|---|
Supplier Part Number | 23666-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/23666m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 51-15-0 |