Cayman Mepenzolate (Bromide); Purity- Greater Than Or Equal To 95

Frovatriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT_1B and 5-HT_1D (K_is = 2.51 and 3.98 nM, respectively).^, It is selective for 5-HT_1B and 5-HT_1D over 5-HT_1A, 5-HT_1E, 5-HT_1F, 5-HT_2A, 5-HT_2C, 5-HT₃, and 5-HT₇ receptors, as well as dopamine D₁, D₂, and D₃, histamine H₁, and α₁-adrenergic receptors (K_is = >50 nM). Frovatriptan induces contractions in human basilar arteries isolated post-mortem, coronary arteries from transplant recipient hearts, and coronary arteries from donor hearts unsuitable for transplantation (EC₅₀s = 13.8, 41.69, and 15.49 nM, respectively). It increases carotid vascular resistance in closed-chest and open-chest anesthetized dogs (ED₅₀s = 6 and 1 nmol/kg, i.v., respectively). Formulations containing frovatriptan have been used in the treatment of migraines.

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