We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman Ns 11394; Purity- Greater Than Or Equal To 98%; Size- 1 Mg
NETA PART: | CAYM-23872-1 |
MFG.PART: | 23872-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
NS 11394 is an orally bioavailable positive allosteric modulator of the GABAA receptor (Ki = 0.423 nM in rat cortical membranes). It is selective for GABAA receptors containing α1, α2, α3, or α5 subunits (Kis = 0.41, 0.84, 0.497, and 0.119 nM, respectively) over receptors containing α4 or α6 subunits (Kis = 324 or 1,009 nM, respectively). In X. laevis oocytes, NS 11394 modulates GABA responses via receptors containing the subunits α3 and α5, with maximal potentiation rates of 52% and 78%, respectively, relative to diazepam (Item No. ). In vivo, NS 11394 inhibits the binding of [3H]flunitrazepam to benzodiazepine receptors in the forebrain of mice and rats, with respective EC50 values of 0.38 and 1.3 mg/kg at 30 minutes and 0.49 and 0.69 mg/kg at 120 minutes following oral administration. NS 11394 (1-30 mg/kg) attenuates spontaneous nociceptive behaviors to formalin and capsaicin (Item No. ) injections in a rat model of neuropathic pain.
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 33 mg/ml3
- DMSO: 33 mg/ml3
- Ethanol: 33 mg/ml3
- Ethanol:PBS(pH 7.2) (1:5): 0.16 mg/ml
Shipping & Storage Information
SKU | CAYM-23872-1 |
---|---|
Supplier Part Number | 23872-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/23872m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 951650-22-9 |