Cayman Dm1-Smcc; Purity- Greater Than Or Equal To 98%; Size- 10 M

Coptisine is an isoquinoline alkaloid that has been found in Coptis chinensis and has diverse biological activities, including antioxidant, enzyme inhibitory, antiproliferative, and anti‑hypercholesterolemic properties.^,,,, It inhibits the production of reactive oxygen species (ROS) in isolated kidney mitochondria in a 2,7-dichlorodihydrofluorescein diacetate (DCFH-DA; Item No. ) assay (IC₅₀ = 48.93 μM). Coptisine inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) but not β-secretase 1 (BACE1) in cell-free enzyme assays (IC₅₀s = 0.8, 5.81, and >100 μM, respectively). It also inhibits indoleamine 2,3-dioxygenase (IDO) in vitro (IC₅₀ = 6.3 μM), as well as organic cation transporter 1 (OCT1), OCT2, and OCT3 in MDCK cells (IC₅₀s = 0.931, 2.27, and 2.27 μM, respectively, for the human transporters).^, It inhibits proliferation of A549, H460, and H2170 human lung cancer cells with IC₅₀ values of 18.09, 29.5, and 21.6 μM, respectively. Coptisine (70.05 mg/kg) decreases total serum cholesterol, triglyceride, and LDL-cholesterol levels and increases serum HDL-cholesterol levels in Syrian golden hamsters fed a high-fat and high-cholesterol diet.

WARNING This product is not for human or veterinary use.