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Cayman Nd-630; Purity- Greater Than Or Equal To 98%; Size- 1 Mg;
NETA PART: | CAYM-23961-1 |
MFG.PART: | 23961-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
ND-630 is an allosteric inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits ACC1 and ACC2 activity (IC50s = 2.1 and 6.1 nM, respectively, for the human enzymes). It is selective for ACC over 101 enzymes, receptors, growth factors, transporters, and ion channels up to a concentration of 10 µM. ND-630 prevents dimerization of ACC by interacting within the phosphopeptide-acceptor and dimerization site. It reduces fatty acid synthesis (EC50s = 66 and 9 nM in 10% FBS and serum-free media, respectively) and increases fatty acid oxidation in HepG2 cells. ND-630 reduces hepatic steatosis in a rat model of diet-induced obesity and in Zucker diabetic rats. It also improves insulin secretion stimulated by glucose and reduces hemoglobin A1c levels by 0.9% in Zucker diabetic rats.
WARNING This product is not for human or veterinary use.
Technical Information
- Firsocostat
- GS-0976
- DMF: 10 mg/ml
- DMSO: 5 mg/ml
- Ethanol: 2 mg/ml
Shipping & Storage Information
SKU | CAYM-23961-1 |
---|---|
Supplier Part Number | 23961-1 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/23961m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 1434635-54-7 |