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Cayman Pd 198306; Purity- Greater Than Or Equal To 98%; Size- 1 M
Cayman Pd 198306; Purity- Greater Than Or Equal To 98%; Size- 1 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$67.00
Your Price
$67.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-23966-1 |
| MFG.PART: | 23966-1 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
PD 198306 is an orally bioavailable and potent inhibitor of MAPK kinase 1/2 (MEK1/2; IC50 = 8 nM). It is selective for MEK1/2 over ERK, c-Src, PI3Kγ, and cyclin-dependent kinases (IC50s = >1 μM). PD 198306 (3-100 μM) reduces ERK1/2 phosphorylation and inhibits growth of HL-60 cells in vitro. In vivo, PD 198306 (10-30 mg/kg) reduces ERK1/2 phosphorylation and matrix metalloproteinase-1 (MMP-1) expression in a dose-dependent manner in a rabbit model of osteoarthritis. It also reduces ERK1/2 activity in the lumbar spinal cord and blocks static allodynia in rat models of neuropathic pain induced by streptozotocin (Item No. ) or chronic constriction injury.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-(cyclopropyl
CAS Number
212631-61-3
Molecular Formula
C18H16F3IN2O2
Formula Weight
476.2
Purity
≥98%
Formulation
A solid
Solubility
- DMSO: 100 mM
- Ethanol: 100 mM
SMILES
CC1=CC(I)=CC=C1NC2=C(F)C(F)=C(F)C=C2C(NOCC3CC3)=O
InChi Code
InChI=1S/C18H16F3IN2O2/c1-9-6-11(22)4-5-14(9)23-17-12(7-13(19)15(20)16(17)21)18(25)24-26-8-10-2-3-10/h4-7,10,23H,2-3,8H2,1H3,(H,24,25)
InChi Key
UHAXDAKQGVISBZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-23966-1 |
|---|---|
| Supplier Part Number | 23966-1 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/23966m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 212631-61-3 |