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Cayman Substance P (Trifluoroacetate Salt); Purity- Greater Than
NETA PART: | CAYM-24035-1 |
MFG.PART: | 24035-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
AT-121 is a dual μ-opioid and nociceptin receptor partial agonist (Kis = 16.49 and 3.67 nM, respectively). It stimulates [35S]GTPγS binding to cell membranes expressing μ-opioid or nociceptin receptors (EC50s = 19.6 and 34.7 nM, respectively). AT-121 (0.003-0.03 mg/kg) decreases capsaicin-induced thermal allodynia without increasing scratching activity in rhesus monkeys in a dose-dependent manner. It lacks reinforcing effects, a marker of abuse potential, and reduces oxycodone, but not food pellet, reinforcement in a drug self-administration assay in rhesus monkeys when administered at doses ranging from 0.3 to 10 μg/kg per injection. AT-121 (0.01 or 0.03 mg/kg) does not induce hyperalgesia, a marker of tolerance development, in rhesus monkeys.
WARNING This product is not for human or veterinary use.
Technical Information
- Chloroform: 10 mg/ml
- DMF: miscible
- DMSO: miscible
- Ethanol: miscible
- Ethanol:PBS (pH 7.2) (1:20): 50µg/ml
Shipping & Storage Information
SKU | CAYM-24035-1 |
---|---|
Supplier Part Number | 24035-1 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/24035m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |