Cayman Substance P (Trifluoroacetate Salt); Purity- Greater Than

Cayman Substance P (Trifluoroacetate Salt); Purity- Greater Than Or Equal To 95%; Size- 25 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)

List Price $479.00 Your Price $479.00

HOW MUCH YOU SAVE:

0.00 %

Skip to the end of the images gallery

Skip to the beginning of the images gallery

NETA PART:	CAYM-24035-25
MFG.PART:	24035-25
UNSPSC:	12352200
Manufacturer:	Cayman

Description

Product Description

Substance P is tachykinin neuropeptide that selectively binds to neurokinin 1 (NK₁) receptors (K_is = 0.14 and 300 nM for NK₁ and NK₃, respectively) and has diverse biological activities.^1,2 It is an endogenous peptide expressed in the central and peripheral nervous systems, including the enteric nervous system and in immune cells.² Substance P is released with other neurotransmitters in the dorsal horn of the spinal cord following noxious peripheral stimulation and induces pain through NK₁ receptors.³ The NK₁ receptor is internalized following substance P binding, and in a rat hindpaw model of inflammation it is internalized in a greater number of spinal cord neurons following a mechanical or non-noxious stimuli, indicating a role for substance P in inflammation and hyperalgesia.⁴ Substance P is also involved in depression, anxiety, seizures, and emesis among other functions.²

WARNING This product is not for human or veterinary use.

Technical Information

Formal Name

(S)-2-((S)-1-(L-arginyl-L-prolyl-L-lysyl)pyrrolidine-2-carboxamido)-N1-((S)-5-amino-1-(((S)-1-(((S)-1-((2-(((S)-1-(((S)-1-amino-4-(methylthio)-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1,5-dioxopentan-2-yl)pentanediamide, trifluoroacetate salt

CAS Number

148470-19-3

Molecular Formula

C₆₃H₉₈N₁₈O₁₃S • XCF₃COOH

Formula Weight

1347.6

Purity

≥95%

Formulation(Request formulation change)

A lyophilized powder

Solubility(Learn about Variance in Solubility)

Water: 1 mg/ml

SMILES

O=C(N[C@@H](CCCCN)C(N1CCC[C@H]1C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N)=O)CCSC)=O)CC(C)C)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)[C@H]4N(C([C@@H](N)CCCNC(N)=N)=O)CCC4.FC(F)(C(O)=O)F

InChi Code

InChI=1S/C63H98N18O13S.C2HF3O2/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70;3-2(4,5)1(6)7/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71);(H,6,7)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-;/m0./s1

InChi Key

HJUBUMANGKVTGH-HDKZLILXSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Room Temperature in continental US; may vary elsewhere

Stability

≥ 4 years

Specifications

More Information
SKU	CAYM-24035-25
Supplier Part Number	24035-25
UM	EA
UNSPSC	12352200
Manufacturer	Cayman
MSDS URL	https://www.caymanchem.com/msdss/24035m.pdf
Temperature	-20
Refrigerated-Frozen	Refrigerated
CountryOfOrigin	US
ProductLine	CAYM
Qty	25
MinOrderQty	1
Weight	7.00
Lead Time	2 Business Days
Hazardous	N

Provide Content Correction

Cayman Substance P (Trifluoroacetate Salt); Purity- Greater Than

Product Description

Technical Information

Shipping & Storage Information

Product Title