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Cayman Alphacgrp (Human) (Trifluoroacetate Salt); Purity- Great
NETA PART: | CAYM-24405-1 |
MFG.PART: | 24405-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
ML-314 is a neurotensin-1 receptor (NTS1) agonist., It is selective for NTS1 over NTS2 in a cell-based assay of receptor/β-arrestin complex formation (EC50s = 2 and >80 μM, respectively) but is inactive in an NTS1 calcium flux assay (EC50 = >80 μM) indicating that, in contrast to other NTS1 agonists, it does not signal through the traditional Gq-coupled pathway. ML-314 is also a positive allosteric modulator of NTS1 that increases binding of radiolabeled neurotensin (Item No. ) to NTS1 in a concentration-dependent manner. It reduces locomotion in dopamine transporter knockout mice and methamphetamine-exposed mice when administered at doses of 20 and 10 to 30 mg/kg, respectively. ML-314 (30 mg/kg) also reduces methamphetamine self-administration in rats.
WARNING This product is not for human or veterinary use.
Technical Information
- DMSO: >100mM
Shipping & Storage Information
SKU | CAYM-24405-1 |
---|---|
Supplier Part Number | 24405-1 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/24405m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |